A new large-scale, retrospective study has found that patients receiving testosterone replacement therapy (TRT) had significantly lower rates of hip fractures compared to those who did not receive TRT. The research, published in the Journal of the American Academy of Orthopaedic Surgeons, adds to growing evidence that testosterone therapy may play a protective role in bone health—especially in older adults at risk for fragility fractures.
Key Findings at a Glance
- Study Design: Matched retrospective analysis of 301,724 patients using the PearlDiver Mariner165 database.
- Groups Compared: Patients on TRT for at least 3 months vs. a control group with no TRT.
- Hip Fracture Incidence:
- TRT Group: 0.13%
- Control Group: 0.25%
- Result: TRT was associated with a 1.9x lower risk of hip fractures.
- TRT Group: 0.13%
- Statistical Significance: P < 0.001
- Adjusted Odds Ratio (aOR): 0.58 overall, indicating a 42% reduction in hip fracture odds with TRT use.
Effect Observed in Both Men and Women
While TRT is primarily prescribed for men with hypogonadism, the study found reduced hip fracture risk in both male and female patients:
- Men: aOR 0.61 (39% reduced risk)
- Women: aOR 0.49 (51% reduced risk)
Why It Matters
Hip fractures are a major cause of morbidity and mortality, especially in older adults. Recovery is often long and complicated, and many patients never regain their previous level of mobility or independence. This study suggests that TRT may help reduce the risk of these potentially life-altering injuries.
Researchers believe the protective effect may be due to TRT’s ability to improve bone mineral density, slow bone loss, and enhance musculoskeletal function—all of which contribute to reducing fracture risk.
What This Means for Prescribers
This research strengthens the case for considering TRT not only for symptomatic testosterone deficiency but also as a potential strategy to support bone health. While more research is needed, especially prospective studies, the current data supports that appropriately selected patients on TRT may benefit from a reduced risk of osteoporotic fractures like those of the hip.
Learn More About TRT Compounding Options
At Massey Drugs, we compound high-quality testosterone therapies tailored to your patient’s needs. We offer injectable and transdermal options with fast turnaround times and expert pharmacist support.
If you’re a provider interested in prescribing TRT or learning more about our compounded men’s health formulations, contact us or sign up for our Practitioner Portal to access our prescription forms and pricing.