Mitomycin 0.02% (PF) Ophthalmic Solution
Quantity: 8 mL
Price: Call 833.540.3500 or login to the Practitioner Portal for pricing.
Sterile compounded ophthalmic preparation available by prescription. The FDA does not review any compounded medication for safety or efficacy.
What is Mitomycin 0.02% (PF) Ophthalmic Solution?
Mitomycin 0.02% (PF) ophthalmic solution is a preservative-free compounded sterile eye drop formulated for ophthalmic use.
Mitomycin C is derived from Streptomyces species and functions as a cytotoxic antimetabolite, meaning it inhibits DNA synthesis and cellular replication. In ophthalmology, this effect is leveraged to:
- Reduce fibroblast activity
- Limit scar tissue formation
- Support surgical outcomes in procedures where healing response must be controlled
Its use has been described across multiple ophthalmic applications, including glaucoma surgery, ocular surface disease, and select neoplastic conditions.
What is the Mechanism of Action?
Mitomycin acts as an alkylating agent that:
- Cross-links DNA strands
- Inhibits DNA replication and protein synthesis
- Suppresses rapidly dividing cells, including fibroblasts
In ophthalmic applications, this mechanism is particularly important because:
- Fibroblast proliferation contributes to postoperative scarring
- Excessive healing can compromise surgical outcomes (e.g., filtration failure in glaucoma surgery)
- Controlled inhibition of cellular activity can improve long-term results
This anti-fibrotic effect is why mitomycin is commonly used as an adjunct in ophthalmic procedures.
Clinical Scenarios Where Ophthalmologists Explore Mitomycin (PF) 0.02% Eye Drops
Ophthalmologists may consider this compounded formulation in scenarios such as:
- Glaucoma filtration surgery (e.g., trabeculectomy) to reduce scarring and improve surgical success
- Ocular surface procedures where modulation of healing is desired
- Conjunctival scarring or fibrosis management
- Ocular surface neoplasia or abnormal cell proliferation, when antimetabolite therapy is part of the treatment plan
- Postoperative management strategies requiring customized concentrations or delivery methods
Mitomycin has been shown to help inhibit fibroblast-driven scarring, which is a key factor in glaucoma surgery outcomes. Use is determined by the treating ophthalmologist based on the procedure, patient risk factors, and clinical goals.
Why Ophthalmologists Choose Massey Drugs
- Sterile compounding laboratory experienced in ophthalmic preparations
- Preservative-free formulations tailored for ocular use
- Direct pharmacist access for clinical questions
- Fast turnaround with patient shipment typically within 24–48 hours
- Experience working with corneal specialists and surgical practices
- NABP Accredited Compounding Pharmacy
States We Serve
Massey Drugs is a sterile ophthalmic compounding pharmacy licensed to ship ophthalmic solutions to patients in: Alabama, Tennessee, Mississippi, Louisiana, Georgia, Florida, North Carolina, South Carolina, Kentucky, Illinois, Indiana, Ohio, Pennsylvania, New York, Connecticut, and Texas.
How to Prescribe Mitomycin 0.02% (PF) Ophthalmic Solution
Download Rx Blank from the Practitioner Portal and send to Massey Drugs:
FAX: 800.637.2601
Phone: 833.540.3500
OR
e-Scribe: NPI#: 1295756245 | NCPCP#: 0127553
Massey Drugs | Cloverdale Road
Upon receipt of prescription, Massey Drugs contacts the patient to confirm shipping address and credit card payment.
Medication ships to patient in 24-48 hours once processed.
Massey Drugs provides competitively priced compounded ophthalmic eye drops with transparent, prescriber-accessible pricing. All compound pricing can be viewed in our Practitioner Portal so costs can be communicated to patients before prescribing.
Speak with a Pharmacist
If you have questions about ophthalmic compounding, formulation options, or whether this therapy may be appropriate for a specific clinical scenario, our pharmacists are available to consult. Call 833-540-3500 or contact us.
Frequentley Asked Questions
How does mitomycin work in the eye?
Mitomycin inhibits DNA synthesis and fibroblast proliferation, helping reduce scar tissue formation that can interfere with surgical outcomes.
Why is mitomycin used in glaucoma surgery?
Mitomycin is used to reduce postoperative scarring, which can block fluid drainage and lead to surgical failure. Its use helps improve long-term intraocular pressure control.
Is this formulation commercially available?
No. Preservative-free ophthalmic mitomycin at this concentration is typically compounded for patient-specific use.
References
Use as a Chemotherapeutic Agent:
https://pubmed.ncbi.nlm.nih.gov/17181449/
Use for Cancer Treatment:
https://pubmed.ncbi.nlm.nih.gov/19111031/
https://pubmed.ncbi.nlm.nih.gov/19724215/
https://pubmed.ncbi.nlm.nih.gov/23680759/
Use for Conjunctiva Treatment:
https://pubmed.ncbi.nlm.nih.gov/1791389/
Use for Glaucoma:
https://pubmed.ncbi.nlm.nih.gov/9787364/
Concentration Accuracy:
https://pubmed.ncbi.nlm.nih.gov/26661632/
Additional Ophthalmic Compounding Capabilities
- Post-operative Care
- Emergency & Infection Management
- Emergency & Corneal Scarring Support
- Glaucoma Compounding
- Myopia Management
Explore our full range of ophthalmic compounding capabilities.