Chlorhexidine Gluconate 0.02% Ophthalmic Solution

Chlorhexidine Gluconate 0.02% Ophthalmic Solution

Chlorhexidine Gluconate 0.02% Ophthalmic Drops

Quantity: 8 mL
Price: $110 + Next Day Air shipping
Sig: Place 1 drop in affected eye every hour while awake.

Sterile compounded ophthalmic preparation available by prescription. The FDA does not review any compounded medication for safety or efficacy. 

What is Chlorhexidine Gluconate 0.02% Ophthalmic Solution?

Chlorhexidine gluconate 0.02% ophthalmic solution is a compounded sterile preparation formulated for topical ophthalmic use.

Chlorhexidine is an antiseptic agent with documented anti-amoebic activity. Within ophthalmology, it is most often referenced as part of treatment approaches for Acanthamoeba keratitis, either alone or in combination with other topical agents.

Due to the complexity of corneal infections and variability in presentation, treatment regimens are individualized and may involve intensive dosing schedules, particularly in early stages of care.

What is the Mechanism of Action?

Chlorhexidine is classified as a biguanide antiseptic.

In ophthalmic infectious disease applications, biguanides are valued for their ability to:

  • Disrupt microbial cell membranes
  • Alter cellular permeability
  • Exhibit activity against both trophozoite and cyst forms of Acanthamoeba

This dual-form activity is clinically relevant because cyst forms are more resistant and can contribute to persistent or recurrent infection. Chlorhexidine may be used alone or as part of a broader treatment regimen depending on provider preference and clinical response.

Clinical Scenarios Where Ophthalmologists Explore Chlorhexidine Gluconate 0.02% Eye Drops

Ophthalmologists may consider this compounded formulation in scenarios such as:

  • Suspected or confirmed Acanthamoeba keratitis
  • Contact lens–associated keratitis with concern for amoebic infection
  • Severe or atypical keratitis presentations, including ring infiltrates
  • Treatment-resistant corneal infections where standard therapies have not achieved response
  • Combination anti-amoebic therapy, when multiple agents are used
  • Cases requiring a non-commercial ophthalmic concentration

These cases are typically managed by ophthalmologists experienced in corneal disease and infectious keratitis.

Why Ophthalmologists Choose Massey Drugs

  • Sterile compounding laboratory experienced in ophthalmic preparations
  • Preservative-free formulations tailored for ocular use
  • Direct pharmacist access for clinical questions
  • Fast turnaround with patient shipment typically within 24–48 hours
  • Experience working with corneal specialists and surgical practices
  • NABP Accredited Compounding Pharmacy

States We Serve

States where Massey Drugs ships compounded medications.

Massey Drugs is a sterile ophthalmic compounding pharmacy licensed to ship ophthalmic solutions to patients in: Alabama, Tennessee, Mississippi, Louisiana, Georgia, Florida, North Carolina, South Carolina, Kentucky, Illinois, Indiana, Ohio, Pennsylvania, New York, Connecticut, and Texas.

How to Prescribe Chlorhexidine Gluconate 0.02% Ophthalmic Solution

Download Rx Blank from the Practitioner Portal and send to Massey Drugs:

FAX: 800.637.2601
Phone: 833.540.3500
OR

e-Scribe: NPI#: 1295756245 | NCPCP#: 0127553
Massey Drugs | Cloverdale Road 

Upon receipt of prescription, Massey Drugs contacts the patient to confirm shipping address and credit card payment. 

Medication ships to patient Next Day Air once processed.

Massey Drugs provides competitively priced compounded ophthalmic eye drops with transparent, prescriber-accessible pricing. All compound pricing can be viewed in our Practitioner Portal so costs can be communicated to patients before prescribing.

Speak with a Pharmacist

If you have questions about ophthalmic compounding, formulation options, or whether this therapy may be appropriate for a specific clinical scenario, our pharmacists are available to consult. Call 833-540-3500 or contact us.

Frequentley Asked Questions

Is chlorhexidine 0.02% available commercially as an eye drop?

No. Chlorhexidine 0.02% ophthalmic solution is not widely available as a commercial product and is typically prepared by a compounding pharmacy when prescribed.

Treatment approaches vary. It may be used alone or in combination with other topical agents depending on the clinical scenario and provider preference.

Ophthalmologists may consider it in suspected or confirmed amoebic keratitis, particularly in contact lens–related infections or cases that are not responding to initial therapy.

Additional Ophthalmic Compounding Capabilities

We compound additional sterile ophthalmic therapies used for: 

  • Post-operative Care
  • Emergency & Infection Management
  • Emergency & Corneal Scarring Support
  • Glaucoma Compounding
  • Myopia Management

Explore our full range of ophthalmic compounding capabilities.