Fluorouracil (5-FU) 1% Preservative-Free Ophthalmic Solution
Quantity: 7 mL
Price: $90
Sterile compounded ophthalmic preparation available by prescription. The FDA does not review any compounded medication for safety or efficacy.
What is Fluorouracil 1% Preservative-Free Ophthalmic Solution?
Fluorouracil 1% ophthalmic solution is a compounded sterile, preservative-free eye drop formulated for topical ophthalmic use.
Fluorouracil (5-FU) is a pyrimidine analog that interferes with DNA synthesis, making it effective at inhibiting the growth of rapidly dividing cells. In ophthalmology, this property is leveraged to:
- Target abnormal epithelial cell growth
- Reduce fibroblast proliferation
- Support treatment strategies where controlled inhibition of healing is beneficial
Compounding allows for a patient-specific, preservative-free formulation suitable for ophthalmic use.
What is the Mechanism of Action?
Fluorouracil works by:
- Inhibiting thymidylate synthase, a key enzyme in DNA synthesis
- Disrupting RNA and DNA production
- Preventing replication of rapidly dividing cells
In ophthalmic applications, this mechanism is used to:
- Suppress abnormal epithelial proliferation
- Inhibit fibroblast activity
- Reduce scar formation following certain procedures
These effects make fluorouracil a useful adjunct in managing conditions where cellular overgrowth or scarring impacts outcomes.
Clinical Scenarios Where Ophthalmologists Explore Fluorouracil 1% Ophthalmic Solution
Ophthalmologists may consider this compounded formulation in scenarios such as:
- Ocular surface neoplasia (e.g., conjunctival intraepithelial neoplasia)
- Adjunctive therapy in glaucoma filtration procedures to reduce scarring
- Conjunctival fibrosis or scarring management
- Postoperative care where modulation of wound healing is desired
- Cases requiring preservative-free formulations for sensitive ocular surfaces
Use is determined by the treating ophthalmologist based on diagnosis, treatment goals, and patient-specific factors.
Why Ophthalmologists Choose Massey Drugs
- Sterile compounding laboratory experienced in ophthalmic preparations
- Preservative-free formulations tailored for ocular use
- Direct pharmacist access for clinical questions
- Fast turnaround with patient shipment typically within 24–48 hours
- Experience working with corneal specialists and surgical practices
- NABP Accredited Compounding Pharmacy
States We Serve
Massey Drugs is a sterile ophthalmic compounding pharmacy licensed to ship ophthalmic solutions to patients in: Alabama, Tennessee, Mississippi, Louisiana, Georgia, Florida, North Carolina, South Carolina, Kentucky, Illinois, Indiana, Ohio, Pennsylvania, New York, Connecticut, and Texas.
How to Prescribe Fluorouracil 1% Ophthalmic Solution
Download Rx Blank from the Practitioner Portal and send to Massey Drugs:
FAX: 800.637.2601
Phone: 833.540.3500
OR
e-Scribe: NPI#: 1295756245 | NCPCP#: 0127553
Massey Drugs | Cloverdale Road
Upon receipt of prescription, Massey Drugs contacts the patient to confirm shipping address and credit card payment.
Medication ships to patient in 24-48 hours once processed.
Massey Drugs provides competitively priced compounded ophthalmic eye drops with transparent, prescriber-accessible pricing. All compound pricing can be viewed in our Practitioner Portal so costs can be communicated to patients before prescribing.
Speak with a Pharmacist
If you have questions about ophthalmic compounding, formulation options, or whether this therapy may be appropriate for a specific clinical scenario, our pharmacists are available to consult. Call 833-540-3500 or contact us.
Frequentley Asked Questions
Is fluorouracil a chemotherapy drug?
It interferes with DNA replication in rapidly dividing cells, helping suppress abnormal growth and reduce fibroblast-driven scarring.
Why is fluorouracil used in glaucoma procedures?
Fluorouracil may be used to reduce postoperative scarring, which can impact the success of filtration procedures.
Is this formulation commercially available?
No. Preservative-free fluorouracil ophthalmic solutions are typically compounded for patient-specific use.
Additional Ophthalmic Compounding Capabilities
We compound additional sterile ophthalmic therapies used for:
- Post-operative Care
- Emergency & Infection Management
- Emergency & Corneal Scarring Support
- Glaucoma Compounding
- Myopia Management
Explore our full range of ophthalmic compounding capabilities.